An integrative approach towards understanding the structure-function relationship of the epigenetic regulator methyl CpG binding protein 2
Methyl CpG binding protein 2 (MeCP2) is a methylated DNA binding protein which, when mutated, leads to a severe neurodevelopmental disorder known as Rett syndrome (RTT). In the present work I have shown that MeCP2 is a highly unstructured protein with modular organization and harbors nine interspers...
Main Author: | |
---|---|
Language: | ENG |
Published: |
ScholarWorks@UMass Amherst
2010
|
Subjects: | |
Online Access: | https://scholarworks.umass.edu/dissertations/AAI3427531 |