An integrative approach towards understanding the structure-function relationship of the epigenetic regulator methyl CpG binding protein 2

Methyl CpG binding protein 2 (MeCP2) is a methylated DNA binding protein which, when mutated, leads to a severe neurodevelopmental disorder known as Rett syndrome (RTT). In the present work I have shown that MeCP2 is a highly unstructured protein with modular organization and harbors nine interspers...

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Bibliographic Details
Main Author: Ghosh, Rajarshi P
Language:ENG
Published: ScholarWorks@UMass Amherst 2010
Subjects:
Online Access:https://scholarworks.umass.edu/dissertations/AAI3427531