Two new requirements for producing normal ribosomes: (I) A novel helicase is needed for snoRNP biogenesis, and; (II) Pseudoridine modifications in the reaction center are important for ribosome function
Eukaryotic cells contain scores of small nucleolar RNAs (snoRNAs) that are complexed with proteins in particles known as snoRNPs. SnoRNPs function in processing of ribosomal RNA (rRNA) and nucleotide modification of ribosomal and other RNAs that pass through the nucleolus. The modifications involved...
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| Language: | ENG |
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ScholarWorks@UMass Amherst
2002
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| Online Access: | https://scholarworks.umass.edu/dissertations/AAI3039368 |