Computational analysis of transcriptional regulation from local sequence features to three dimensional chromatin domains

Regulation of gene expression spans different levels of complexity: from genomic sequence, transcription factor binding and epigenetics, to three-dimensional chromatin interactions. Data from different individuals such as genetic variations presents an extra dimension to consider. Abnormal activitie...

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Bibliographic Details
Main Author: Chen, Julie Chih-yu
Language:English
Published: University of British Columbia 2016
Online Access:http://hdl.handle.net/2429/59384