Genetic determinants of genome stability and crossover distribution in the nematode Caenorhabditis elegans
Guanine-rich DNA sequences can form secondary structures in vitro. In vivo, helicases are responsible for undoing these structures during DNA replication. In the absence of helicase function, these structures may be unrepaired and undergo mutagenic end-joining processes that generate DNA sequence de...
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| Language: | English |
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University of British Columbia
2016
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| Online Access: | http://hdl.handle.net/2429/56695 |