Parallel synthesis of small molecule compound libraries : isoform selective Rho-Kinase inhibitors
The objective of this thesis was to use parallel synthesis to build small molecule libraries of novel compounds with potential as isoform selective type II rho-kinase (ROCK1/2) inhibitors. Considerable effort is ongoing to identify isoform selective ROCK inhibitors, as hyperactivity of the ROCK is i...
| Main Author: | |
|---|---|
| Language: | English |
| Published: |
University of British Columbia
2015
|
| Online Access: | http://hdl.handle.net/2429/54300 |