The regulation of mitotic spindle orientation by BRCA1 controls the proliferation, polarization and growth arrest of human mammary epithelia
Carriers of mutations in the Breast Cancer 1 (BRCA1) gene have an increased risk to develop breast cancer, which tend to be early-onset, lack expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2, and resemble basal epithelia by gene expression. The phen...
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| Language: | English |
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University of British Columbia
2014
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| Online Access: | http://hdl.handle.net/2429/50210 |