The role of karyopherin-alpha in the pathogenesis of TDP-43 proteinopathy

The role of karyopherin-alpha in the pathogenesis of TDP-43 proteinopathy

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Aberrant cellular processing and targeting of TDP-43 has been implicated in a wide variety of neurological diseases such as frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U) and amyotrophic lateral sclerosis (ALS). These diseases are characterized by the sequestration of TDP-4...

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Bibliographic Details
Main Author:	Armstrong, Bryson Walter
Language:	English
Published:	University of British Columbia 2013
Online Access:	http://hdl.handle.net/2429/45074

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