The role of karyopherin-alpha in the pathogenesis of TDP-43 proteinopathy
Aberrant cellular processing and targeting of TDP-43 has been implicated in a wide variety of neurological diseases such as frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U) and amyotrophic lateral sclerosis (ALS). These diseases are characterized by the sequestration of TDP-4...
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| Language: | English |
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University of British Columbia
2013
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| Online Access: | http://hdl.handle.net/2429/45074 |