Expression, purification, and characterization of RD3, the protein associated with Leber's congenital amaurosis type 12
RD3 is a highly conserved 23 kDa soluble protein expressed in the retinal and testicular tissues required for the trafficking of GC1 (Guanylate Cyclase 1). A lack of expression of this protein, or of GC1, results in a rapid loss of photoreceptor cells after retinal development, indicating their imp...
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| Language: | English |
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University of British Columbia
2013
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| Online Access: | http://hdl.handle.net/2429/44529 |