Synthetic lethality and synthetic cytotoxicity strategies for selective killing of ATM deficient cells
Chromosome instability (CIN) is a hallmark of cancer cells and could, in theory, be exploited in the design of cancer therapeutics. Tumor cells harboring CIN mutations may be dependent on certain DNA repair pathways for viability. Thus, inhibition of specific DNA repair enzymes may enhance the CIN p...
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| Language: | English |
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University of British Columbia
2012
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| Online Access: | http://hdl.handle.net/2429/42081 |