A characterization of glucose-induced downregulation of the glucose dependent insulinotropic polypeptide receptor (GIPR)
The primary role of the incretin hormone, glucose-dependent insulinotropic polypeptide (GIP) is to potentiate the secretion of insulin in a glucose-dependent manner. In humans and rat models with type 2 diabetes, however, this action is impaired as a result of attenuated GIP receptor (GIPR) expre...
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| Language: | English |
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University of British Columbia
2011
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| Online Access: | http://hdl.handle.net/2429/32232 |