Synergism of heat shock protein and histone deacetylase inhibitors in synovial sarcoma
Synovial sarcoma is a cancer of young adults and is fatal in about half of cases. This malignancy carries an SYT-SSX fusion oncoprotein that is not targeted by existing drugs. Recently, we demonstrated that histone deacetylase inhibitors and the heat shock protein 90 inhibitor 17AAG inhibit synovial...
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| Language: | English |
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University of British Columbia
2011
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| Online Access: | http://hdl.handle.net/2429/31907 |