Metoprolol and cardiac carnitine palmitoyltransferase-1 : unravelling a complex interaction in normal and diabetic hearts
Diabetic cardiomyopathy may be initiated or compounded by the heavy reliance of the heart on fatty acids and ketones as metabolic fuels. β-blockers have been proposed to inhibit fatty acid oxidation by decreasing the activity of the enzyme carnitine palmitoyltransferase-1 (CPT-1). By inhibiting fatt...
| Main Author: | |
|---|---|
| Language: | English |
| Published: |
University of British Columbia
2011
|
| Online Access: | http://hdl.handle.net/2429/31489 |