Synthesis and reactivity of 14-membered keto lactones

A convergent synthesis using dithiane alkylations to produce a long chain hydroxy acid, and subsequent macrolactonization of the latter, yielded the 14-membered macrolides 47 and 58. [ Formulas omitted ] Alkylation of 47 with methyl iodide gave a diastereomeric produ...

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Bibliographic Details
Main Author: Maurice, Joseph Roger Luc
Language:English
Published: University of British Columbia 2011
Online Access:http://hdl.handle.net/2429/31129