The role of the dynein motor system on the trafficking of cardiac potassium ion channels
In this thesis, we establish a role for the retrograde dynein motor in mediating the trafficking of cardiac potassium channels. Using dynamitin overexpression to disrupt the dynein motor complex, we demonstrate that dynein disruption doubles Kv1 .5 currents and increases surface Kv1.5 protein levels...
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| Language: | English |
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2010
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| Online Access: | http://hdl.handle.net/2429/17977 |