Improved methodology for the synthesis of bicycle octapeptides
Rigidity is an important property of drugs and small molecule toxins that enhances the affinity for their targets. Amatoxins are highly rigid bicyclic peptides that bind to and consequently inhibit RNA Polymerase II. In this thesis we present an improved methodology for the synthesis of a tryptat...
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| Format: | Others |
| Language: | English |
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2009
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| Online Access: | http://hdl.handle.net/2429/15421 |