Influence of permeating ions on Kv1.5 channel block by nifedipine
Nifedipine antagonizes current flow through both cardiovascular L-type Ca2+ channels and voltage-gated K+ (Kv) channels. Work from our lab has shown that nifedipine blocks human heart Kv1.5 current when channels are expressed in HEK cells, and an open channel block mechanism was suggested. Here,...
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| Format: | Others |
| Language: | English |
| Published: |
2009
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| Online Access: | http://hdl.handle.net/2429/11375 |