Synthesis and reactivity of macrocyclic lactams and dynamic nmr studies of macrocyclic amines and a macrocyclic ketone
Conformationally controlled alkylations of lactams 65, 66, 67 and 68 were investigated. High stereoselectivity was obtained in the alkylation of the dianion of lactams 65, 66 and 67. The alkylation of 65 gave products 92 and 93 in a >99:1 ratio. Alkylation of 66 gave 94 and 95 in a 62:1 ratio,...
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| Format: | Others |
| Language: | English |
| Published: |
2009
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| Online Access: | http://hdl.handle.net/2429/10929 |