Investigation of the Mechanism Underlying the Ubiquitination of O6-Methylguanine-DNA Methyltransferase Induced by Alkylating Agents and Its Clinical Significance
博士 === 國立成功大學 === 基礎醫學研究所 === 107 === The DNA repair enzyme, O6-methylguanine-DNA methyltransferase (MGMT), modulates the cytotoxicity of chemotherapeutic agents related to DNA alkylation of the O6-position of guanine. However, previous studies indicated that alkylating agents such as 1,3-bis(2-chlo...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Others |
| Language: | en_US |
| Published: |
2019
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| Online Access: | http://ndltd.ncl.edu.tw/handle/ez6b43 |