MDM2 Phosphorylation by TTK/hMps1 Promotes Oxidative DNA Damage Response and Repair through Histone H2B Ubiquitination

博士 === 國立臺灣大學 === 微生物學研究所 === 104 === MDM2 is an E3 ubiquitin ligase that targets proteins involved in cell cycle progression. Although many MDM2 substrates have been identified, how its activity is regulated is not fully understood, especially when cells are under oxidative stress. Here we show tha...

Full description

Bibliographic Details
Main Authors: Zheng-Cheng Yu, 余正晟
Other Authors: Sheau-Yann Shieh
Format: Others
Language:en_US
Published: 2015
Online Access:http://ndltd.ncl.edu.tw/handle/75535390421783148120