Multiple Complexes of Long Aliphatic N-Acyltransferases Lead to Synthesis of 2,6-Diacylated/2-Acyl-Substituted Glycopeptide Antibiotics, Effectively Killing Vancomycin-Resistant Enterococcus

博士 === 國立陽明大學 === 微生物及免疫學研究所 === 103 === Teicoplanin A2-2 (Tei)/A40926 is the last-line antibiotic to treat multidrug-resistant Gram-(+) bacterial infections, e.g. methicillin-resistant Staphylococcus aureus (MRSA)/vancomycin-resistant enterococcus (VRE). This class of antibiotics is empowered by th...

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Bibliographic Details
Main Authors: Syue-Yi Lyu, 呂學毅
Other Authors: Tsung-Lin Li
Format: Others
Language:en_US
Published: 2014
Online Access:http://ndltd.ncl.edu.tw/handle/02874825918346407287