Discovery of potential inhibitors against Staphylococcus aureus dihydrofolate reductase by pharmacophore modeling, virtual screening, molecular docking, molecular dynamics simulation and 3D-QSAR modeling
碩士 === 國立臺北科技大學 === 生化與生醫工程研究所 === 103 === Dihydrofolate reductase (DHFR) is an enzyme required for the synthesis of DNA/RNA in Staphylococcus aureus. Inhibition of DHFR has been proven to be a potent strategy for the treatment of S. aureus infection; however, S. aureus has generated drug resistance...
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| Online Access: | http://ndltd.ncl.edu.tw/cgi-bin/gs32/gsweb.cgi/login?o=dnclcdr&s=id=%22103TIT05723019%22.&searchmode=basic |