| Summary: | 碩士 === 國立中興大學 === 食品暨應用生物科技學系所 === 102 === Atherosclerosis and cardiovascular disease are common health problems in the world, especially in developed countries. diseases, hyperlipidemia is regarded as the major risk factor. In these Previous researches suggested that increasing dietary fiber intake could improve hyperlipidemia, and many high-fiber products are available in the market. Soy protein and oligosaccharide have been shown to have promising lipid-lowering effects in many studies. U.S. Food and Drug Administration has claimed that intake of 25 g of soy protein daily may reduce risk factors of cardiovascular disease. In this study, a soy protein oligosaccharide formula which was developed by using soy protein and oligosaccharide was examined for its lipid-lowering ability, by using a hamster model. Hamsters were divided into five groups; they were fed with different high fat diets (with 14% fat, 0.2% cholesterol) and soy protein oligosaccharide formula with different dosages for 8 weeks. Our results showed that the middle-dose group (1X) and high-dose group (2X), compared to the high fat control group (HF), apparently (p < 0.05) decreased serum total cholesterol (20%), high-density lipoprotein cholesterol (12-14%) and low-density lipoprotein cholesterol (30-40%) concentrations. In addition, a significant (p < 0.05) decrease in LDL-C/TC and LDL-C / HDL-C ratio was observed in high-dose group. The results showed that the oligosaccharide portion of the sample was the major component that regulated blood lipids. The liver total cholesterol were significantly (p < 0.05) reduced by 12% in the high-dose group, as compared to the high-fat control group. The moisture in feces is significantly (p < 0.05) increased by 5-12% in the high-dose group. In conclusion, this study suggested that consumption of the soy protein-oligosaccharide formula had a positive effect on regulating blood lipids in middle-dose and high-dose groups, which resulted in the effective reduction in liver cholesterol and increase in fecal moisture content.
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