Using Functional Magnetic Resonance Imaging to Explore Effects of Motor Learning on Functional Connectivity

• Main Authors: Yu-Ling Ye, 葉俞伶
• Other Authors: Ming-Chang Chiang
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/20664786025098910954

碩士 === 國立陽明大學 === 醫學工程研究所 === 101 === We used functional magnetic resonance imaging (fMRI) to explore changes in functional connectivity under the contextual interference (CI) paradigm of motor learning, where practice context was manipulated by presenting multiple tasks in either a repetitive order (lower interference) or an interleaved order (higher interference). We used psycophysiological interaction (PPI) analysis to explore the changes in functional connectivity of the cerebral motor learning network on practicing different motor sequences. On day 1 and 2 of practice, the interleaved practice group had stronger functional connectivity than the repetitive practice group in the bilateral premotor area (PM), the dorsal lateral prefrontal cortex (DLPFC), the supplementary motor area (SMA), and the caudate nucleus. On day 5, however, the repetitive practice group had stronger functional connectivity than the interleaved practice group in the above areas except the caudate nucleus. These findings demonstrate that the stronger functional connectivity is associated with better motor learning and skill retrieval.