| Summary: | 碩士 === 輔仁大學 === 生命科學系碩士班 === 93 === Abstract
The study is aimed to investigate the effects of Bacillus subtilis natto fermentative products on human blood pressure and hematological factors. The fifty-five volunteers aged 40 - 92 years were categorized into four groups by the 6-week treatment ( Control : cellulose or Test : B. subtilis natto fermentative products ) and their preliminary systolic pressure ( Normal pressure: ≦120 mmHg or High pressure:＞120 mmHg ). The four groups are Control-Normal ( CN ), Control-High ( CH ), Test-Normal ( TN ) and Test-High ( TH ).The results showed that (1) the systolic pressure of TH group apparently decreased to 122 ± 3.5 from 133 ± 2.6 mmHg after six weeks ( p < 0.05 ); (2) the activity of superoxide dimutase ( SOD ) obviously increased to 807.3 ± 132.78 from 401.6 ± 76.80 U/g Hb in TH group after two weeks and it also rises to 684.6 ± 99.39 from 235.1 ± 16.58U/g Hb in TN group after six weeks ( p < 0.05 ); (3) the concentration of malonaldehyde, the end product of lipid peroxidation, was risen to 958.8 ± 399.64 form 371.2 ± 39.89 nmol /mL in the CN group ( p < 0.05 ); (4) the activities of creatine kinase ( CK ), lactate dehydrogenase ( LDH ), the cholesterols, and glutathione peroxidase ( GPx ) were not found statistically different; (5) In whole blood cell counting analysis, the number of erythrocyte, the hematocrit and the content of hemoglobin were analyzed to be statistically less than those measured before the treatment, but all these three results were within the normal range. The amount of leukocyte, lymphocyte, neutrophil, monocyte, eosinophil and basophil were not found statistically different. Conclusively, the results showed that B.subtilis natto fermentative products seem to be capable of reducing the systolic pressure and enhancing the activity of SOD in the high blood pressure group. To realize the mechanism to lower the systolic pressure and to enhance SOD activity, the further study should be carried out.
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