| Summary: | 碩士 === 中山醫學大學 === 營養學研究所 === 93 === Milk is one of the important food in our life. Antihypertensive effect have been found from enzymatic hydrolysates of bovine caseins. This study was conducted to determine whether the casein hydrolysate CEI-12 has the effect on blood pressure down regulation in hypertensive subjects and also to discuss the possible mechanism.
A total of 48 cases successfully completed the intervention study. All of them have mild hypertension or high normal blood pressure. All subjects did not take antihypertensive medication and were randomly assigned to experimental group and control group. The experimental group ingested casein hydrolysate tablets containing 227.88 mg CEI-12 daily. The control group ingested the same amount of placebo tablets. The CEI-12 or placebo tablets were administered for 4 weeks after 2 weeks of run-in period. 2 weeks after the end of administration were follow-up period. During the follow-up period, neither tablet was given to either group. Blood pressure (BP), serium lipid, body composition were measured before and after experimental period. To realize the possible mechanism, levels of angiotensin Ι, angiotensinⅡ and aldosterone were measured. Result clearly showed that BP, angiotensinⅡ, aldosterone were significantly decreased after 4 weeks treatment in the experimental group.
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