| Summary: | 碩士 === 東海大學 === 食品科學系 === 92 === Chitosans of low (0~10%), middle (40~50%) and high (＞85%) deacetylation degrees were prepared from chitin, then treated wigh 12 N HCl into colloidal chitosans. Chitsons and colloidal chitosans were individually added at different concentrations of 2.5, 5.0, 7.5, 10.0% to basic diet, high fat diet and high cholesterol diet those were feed in mice. Chitosans and colloidal chitosan were compared on some properties such as internal structure（Scanning Electron Microscopy, SEM）, hydrolyzing degree, viscosity, molecular weight and deacetylation degree, also on biological activities of mice such as fecal fat, mineral(Ca, Mg, Fe) and protein, feed intake, body weight gain and cholesterol and triglyceride contents within liver and plasma.
As a result, colloidal chitosans had more loosening in internal structure, higher hydrolyzing and deacetylation degrees and lower viscosity and molecular weight than chitosans. On the influence of adding chitosans or colloidal chitosans into the basic diet, high fat diet and high cholesterol diet to the biological activities of mice, the higher deacetylation degree or concentration the higher fecal fat, mineral and protein excretion, the lower body weight gain and cholesterol and triglyceride contents in liver and plasma. Both types of chitosans gave an insignificant effect on the feed- intake except at high deacetylated ones were used at a high concentration. Colloidal chotosans showed a higher fecal fat but lower fecal minerals and protein, body weight gain and liver and plasma cholesterol and triglyceride contents than chitosans.
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