Extrinsic Substrate Stiffness Regulates Chondrocyte Phenotype through Actin Remodeling and MRTF Mechanotransduction Pathway
To obtain a cell source for cartilage tissue engineering primary cells are passaged on polystyrene dishes to increase cell number however, this stiff environment results in dedifferentiation. This study evaluates the role of microenvironment stiffness on regulation of passaged chondrocyte phenotype....
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| Language: | en_ca |
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2014
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| Online Access: | http://hdl.handle.net/1807/65591 |