Design of a Bioreactor to Mimic Hemodynamic Shear Stresses on Endothelial Cells in Microfluidic Systems

Design of a Bioreactor to Mimic Hemodynamic Shear Stresses on Endothelial Cells in Microfluidic Systems

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The mechanisms behind cardiovascular disease (CVD) initiation and progression are not fully elucidated. It is hypothesized that blood flow patterns regulate endothelial cell (EC) function to affect the progression of CVDs. A system that subjects ECs to physiologically-relevant shear stress waveforms...

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Bibliographic Details
Main Author: Lightstone, Noam S.
Other Authors: Simmons, Craig A.
Language:en_ca
Published: 2014
Subjects:
Endothelial cell
Bioreactor
Flow loop
Cardiovascular disease
CVD
Waveform
Microfluidics
Microfluidic devices
Hemodynamics
EC
Shear stress
Shear
Pump
Actuator
Mechanical engineering
Biomedical engineering
PIV
Particle image velocimetry
Fluid dynamics
Fluid mechanics
Pressure
Model
Syringe
Peristaltic
Blood
Blood flow
Wall shear stress
Womersley number
Womersley
Purday
Physiological
Flowmeter
Sinusoid
Sinusoidal
Disturbed
Non-disturbed
Undisturbed
Oscillatory
Pulsatile
In vivo
In vitro
0548
0541
Online Access:http://hdl.handle.net/1807/65572

Internet

http://hdl.handle.net/1807/65572

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