Development of a Novel Pck-1: eGFP Reporter Zebrafish Line for the Discovery and Evaluation of Potential Anti-Diabetic Drugs

Development of a Novel Pck-1: eGFP Reporter Zebrafish Line for the Discovery and Evaluation of Potential Anti-Diabetic Drugs

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Overexpression of Phosphoenolpyruvate carboxykinase - cytosolic (PEPCK, encoded by Pck-1 gene) has been found to be associated with the prevalence of hyperglycemia in Type 2 Diabetes Mellitus (T2DM) patients. The Pck-1 enzyme catalyzes the rate limiting step in endogenous glucose production. The aim...

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Bibliographic Details
Main Author: Hui, Wing
Other Authors: Wen, Xiao-Yan
Language:en_ca
Published: 2013
Subjects:
Diabetes Mellitus
gluconeogenesis
PEPCK
Pck-1
zebrafish
drug discovery
transgenics
reporter line
high throughput screening
transposon
gene regulation
novel drugs
drug screen
microinjection
deletional analysis
physiology
0719
Online Access:http://hdl.handle.net/1807/42881

Internet

http://hdl.handle.net/1807/42881

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