Neuronal UV-Initiated Apoptosis is Prevented By 5-Bromo-2’-Deoxyuridine (BrdU) Or A Deficiency in Cockayne Syndrome B Or Xeroderma Pigmentosum A

Neuronal UV-Initiated Apoptosis is Prevented By 5-Bromo-2’-Deoxyuridine (BrdU) Or A Deficiency in Cockayne Syndrome B Or Xeroderma Pigmentosum A

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This project addressed mechanisms of the neuronal DNA damage response after treatment with the model DNA damaging agent ultraviolet light (UV). The thymidine analogue, 5-bromo-2’-deoxyuridine (BrdU) protected against UV-initiated neuronal apoptosis in a concentration-dependent manner (p<0.001). B...

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Bibliographic Details
Main Author: Rajakulendran, Nishani
Other Authors: Laposa, Rebecca
Language:en_ca
Published: 2012
Subjects:
Neuron
DNA repair
BrdU
XPA
CSB
DNA damage
0419
Online Access:http://hdl.handle.net/1807/42406

Internet

http://hdl.handle.net/1807/42406

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