Molecular Mechanisms and Determinants of Species Sensitivity in Thalidomide Teratogenesis
The expanding therapeutic use of thalidomide (TD) remains limited by its species-specific teratogenicity in humans and rabbits, but not rodents. The R and S isomers of TD may be selectively responsible for its respective therapeutic and teratogenic effects, but rapid in vivo racemization makes t...
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| Language: | en_ca |
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2012
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| Online Access: | http://hdl.handle.net/1807/36210 |