Generation of a Murine Model for Renal Cell Carcinoma by Overexpression of HIF2α

Generation of a Murine Model for Renal Cell Carcinoma by Overexpression of HIF2α

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Renal cell carcinoma (RCC) is the commonest urogenital tumor, characterized by increased expression of hypoxia inducible factors (HIFs). During normoxia, HIFα subunits are targeted for proteasomal degradation by the product of the von Hippel Lindau gene (pVHL). In RCC, mutations in the VHL gene all...

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Bibliographic Details
Main Author:	Shah, Nasir Ali
Other Authors:	Quaggin, Susan E.
Language:	en_ca
Published:	2012
Subjects:	HIF2alpha Hypoxia Kidney Cancer Transgenic Animal Model 0719
Online Access:	http://hdl.handle.net/1807/35156

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