Generation of a Murine Model for Renal Cell Carcinoma by Overexpression of HIF2α
Renal cell carcinoma (RCC) is the commonest urogenital tumor, characterized by increased expression of hypoxia inducible factors (HIFs). During normoxia, HIFα subunits are targeted for proteasomal degradation by the product of the von Hippel Lindau gene (pVHL). In RCC, mutations in the VHL gene all...
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| Language: | en_ca |
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2012
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| Online Access: | http://hdl.handle.net/1807/35156 |