Interaction of Hsp104 with Hsp70: Insight into the Mechanism of Protein Disaggregation
Hsp104 and ClpB are hexameric ATPases that resolubilize aggregated proteins in collaboration with the Hsp70 chaperone system. Hsp104/ClpB functionally interact only with their respective Hsp70 system and this specificity is mapped to the Hsp104/ClpB coiled-coil domain (CCD). We hypothesize that the...
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| Language: | en_ca |
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2013
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| Online Access: | http://hdl.handle.net/1807/35128 |