Involvement of Th17 Pathway in Adverse Drug Reactions: Mechanistic Investigation of Drug-induced Autoimmunity and Drug-induced Liver Injury
Clinical characteristics of idiosyncratic drug reactions (IDRs) suggest that they are immune mediated. Penicillamine-induced autoimmunity in Brown Norway rats was used as a tool for mechanistic studies of this type of IDR. It has been shown that T helper 17 (Th17) cells play a central role in many t...
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| Language: | en_ca |
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2012
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| Online Access: | http://hdl.handle.net/1807/34982 |