Leukocyte Structural Adaptations in Response to Hemodynamic Forces: Tension Transmitted Through VLA-4 Activates Upstream Rap1, PI3K, and Rac-Dependent Actin Polymerization
During inflammation, leukocytes modulate α4β1(VLA-4) integrin avidity in order to rapidly stabilize nascent adhesive contacts to VCAM-1-expressing endothelial cells and resist detachment forces imparted by the flowing blood. Linkage to the actin cytoskeleton is critical for integrin function, yet th...
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| Language: | en_ca |
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2012
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| Online Access: | http://hdl.handle.net/1807/34870 |