Structural and Functional Regulation of the Human Chloride/Proton ClC-5 by ATP and Scaffold NHERF2 Interactions
The chloride/proton antiporter ClC-5 is primarily expressed in the kidney where it aids in re-absorption of proteins from the glomerular filtrate. Functional disruption of ClC-5 causes Dent’s Disease – a renal condition characterized by proteinuria and kidney failure in a third of all cases. The m...
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| Language: | en_ca |
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2010
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| Online Access: | http://hdl.handle.net/1807/32054 |