Molecular Basis of Abnormal Conduction in Mice Over-expressing Endothelin-1
Binary transgenic (BT) mice with doxycycline (DOX)-suppressible cardiac-specific over-expression of endothelin 1 (ET 1) exhibit progressive heart failure, QRS prolongation, and death following DOX withdrawal. However, the molecular basis and reversibility of the electrophysiological abnormalities in...
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| Language: | en_ca |
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2011
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| Online Access: | http://hdl.handle.net/1807/31872 |