Ex vivo Binding of the Agonist PET Radiotracer [11C]-(+)-PHNO to Dopamine D2/D3 Receptors in Rat Brain: Lack of Correspondence to the D2 Recepor Two-affinity-state Model
The dopamine D2 receptor exists in vitro in two states of agonist affinity: a high-affinity state mediating dopamine’s physiological effects, and a physiologically-inert low-affinity state. Our primary goal was to determine the in vivo relevance of this two-affinity-state model for the agonist PET r...
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| Language: | en_ca |
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2010
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| Online Access: | http://hdl.handle.net/1807/26296 |