Global Position Effects on the Epigenetics of Variegated Lentiviral Vector Expression in Embryonic Stem Cells

Global Position Effects on the Epigenetics of Variegated Lentiviral Vector Expression in Embryonic Stem Cells

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Lentivirus efficiently transduce stem cells, however are notably silenced in embryonic stem cells (ESC). Provirus can be silent, expressing, or variegated when clonal single copy ESCs spawn daughters that revert expression despite containing identical integration sites (IS) indicating epigenetic reg...

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Bibliographic Details
Main Author: Khairandish, Arash
Other Authors: Ellis, James
Language:en_ca
Published: 2010
Subjects:
Epigenetics
Retrovirus
Embryonic Stem Cells
Variegation
Viral Expression
Chromatin Structure
Lentivirus
Integration Site
Gene Therapy
Bioinformatics
0369
0307
0720
0379
Online Access:http://hdl.handle.net/1807/25726

Internet

http://hdl.handle.net/1807/25726

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