An Investigation of Nicotine Metabolism in Mice: The Impact of Pharmacological Inhibition and Genetic Influences on Nicotine Pharmacology

An Investigation of Nicotine Metabolism in Mice: The Impact of Pharmacological Inhibition and Genetic Influences on Nicotine Pharmacology

Show other versions (1)

INTRODUCTION: Smoking is one of the single greatest causes of numerous preventable diseases. We were interested in developing an animal model of nicotine metabolism that can be used to examine the effects of potential CYP2A6 inhibitors on nicotine metabolism and nicotine-mediated behaviours. Pharmac...

Full description

Bibliographic Details
Main Author: Siu, Eric C. K.
Other Authors: Tyndale, Rachel
Language:en_ca
Published: 2010
Subjects:
Nicotine
Mice
CYP2A5
CYP2A6
Selegiline
Methoxsalen
Nicotine Self-administration
Genetic
Tail-flick
Hot-plate
Mechanism-based Inhibition
Smoking
Metabolism
0419
Online Access:http://hdl.handle.net/1807/24879

Internet

http://hdl.handle.net/1807/24879

Similar Items