Charaterization of Beta-cell Specific Knockout of UCP2
The whole body UCP2 knockout (UCP2−/−) have enhanced insulin secretion and higher ATP content. However, these changes could be due to indirect effects of extra-pancreatic deletion and therefore, generating beta-cell specific knockout mice (UCP2BKO) is essential. A 90% knockdown of UCP2 protein was...
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| Language: | en_ca |
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2010
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| Online Access: | http://hdl.handle.net/1807/24284 |