Insulin Sensitivity is Enhanced by CGMP-mediated MAPK Inhibition in Rat Adipocytes

Insulin Sensitivity is Enhanced by CGMP-mediated MAPK Inhibition in Rat Adipocytes

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Bradykinin (BK) acts through eNOS to reduce MAPK-mediated feedback inhibition of insulin signalling. Preliminary data suggest that the sGC-cGMP-PKG pathway, a prominent NO target, is involved. Our present study aimed to support the role of this pathway with atrial natriuretic peptide (ANP), which us...

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Bibliographic Details
Main Author:	Thomas, Garry
Other Authors:	Fantus, I. George
Language:	en_ca
Published:	2009
Subjects:	ANP insulin resistance bradykinin diabetes MAPK AKT PKB cGMP PKG 0307
Online Access:	http://hdl.handle.net/1807/18962

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