Insulin Sensitivity is Enhanced by CGMP-mediated MAPK Inhibition in Rat Adipocytes
Bradykinin (BK) acts through eNOS to reduce MAPK-mediated feedback inhibition of insulin signalling. Preliminary data suggest that the sGC-cGMP-PKG pathway, a prominent NO target, is involved. Our present study aimed to support the role of this pathway with atrial natriuretic peptide (ANP), which us...
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| Language: | en_ca |
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2009
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| Online Access: | http://hdl.handle.net/1807/18962 |