Substrate Specificity and Regulation of Nedd4 proteins
Nedd4-1 and Nedd4-2 are closely related E3 ubiquitin protein ligases that contain a C2 domain, 3-4 WW domains, and a catalytic ubiquitin ligase HECT domain. The WW domains of Nedd4 proteins recognize substrates for ubiquitination by binding the sequence L/PPxY (the PY-motif) found in target protein...
| Main Author: | |
|---|---|
| Other Authors: | |
| Language: | en_ca |
| Published: |
2009
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/1807/17454 |