Diabetes and Endoplasmic Reticulum Stress in Pancreatic beta-cells: Effects on Insulin Biosynthesis and beta-cell Apoptosis

Diabetes and Endoplasmic Reticulum Stress in Pancreatic beta-cells: Effects on Insulin Biosynthesis and beta-cell Apoptosis

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Chronic hyperlipidemia (lipotoxicity) and hyperglycemia (glucotoxicity) have recently been shown to induce Endoplasmic Reticulum (ER) stress, which may contribute to pancreatic beta-cell dysfunction in type 2 diabetes. This thesis examined the involvement of ER stress in beta-cell lipotoxicity and g...

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Bibliographic Details
Main Author: Lai, Elida Wing Shan
Other Authors: Volchuk, Allen
Format: Others
Language:en_ca
Published: 2008
Subjects:
pancreatic beta-cells
type 2 diabetes
ER stress
apoptosis
pancreatic beta-cell dysfunction
free fatty acids
lipotoxicity
palmitate
high glucose
hyperglycemia
glucotoxicity
insulin biosynthesis
unfolded protein response
chaperone
GRP78
PDI
INS-1
MIN6
human islets
stable cell line
0379
Online Access:http://hdl.handle.net/1807/11149

Internet

http://hdl.handle.net/1807/11149

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