Characterization of APLF in the Nonhomologous End-joining Pathway
Nonhomologous end-joining (NHEJ) is a major DNA double-strand break (DSB) repair pathway. NHEJ is initiated through DSB recognition by the DNA end-binding heterodimer, Ku, while end-joining is accomplished by the XRCC4-DNA ligase IV (X4L4) complex. This thesis reports that APLF (Aprataxin and Polynu...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Others |
| Language: | en_ca |
| Published: |
2008
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/1807/10435 |