Homology modeling and structural analysis of the antipsychotic drugs receptorome

Homology modeling and structural analysis of the antipsychotic drugs receptorome

Classically it was assumed that the compounds with therapeutic effect exert their action interacting with a single receptor. Nowadays it is widely recognized that the pharmacological effect of most drugs is more complex and involves a set of receptors, some associated to their positive effects and s...

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Bibliographic Details
Main Author: López Muñoz, Laura
Other Authors: Pastor Maeso, Manuel
Format: Doctoral Thesis
Language:English
Published: Universitat Pompeu Fabra 2010
Subjects:
Receptores acoplados a proteína G (GPCR)
Receptor 5-HT2A
Receptor D3
Receptor D2
Ligando
Clozapina
Derivados Benzofuranonas
Risperidona
Olanzapina
esquizofrenia
Derivados Benzofuranonas Derivados Benzolactámico
estudios de relación cuantitativa estructura- acti
Análisis de Componentes Principales (PCA)
métodos de regresión
campos de interacción Molecular (MIF)
Perfil Multireceptorial
modelado por homología
Docking
sitio de unión
interacciones moleculares
selectividad
afinidad de unión
Diana
Meta-Diana
efectos secundarios
fármaco antipsicótico típico
fármaco antipsicótico atípico
agonista
antagonista
membrana
receptoroma
rhodopsina
estructura de rayos X
descriptores moleculares
farmacología
análisis multivariante
procedimiento integrado
diseño de fármacos asistido por ordenador
Computer-aided drug design
Integrated approach
Multivariate analysis
Pharmacology
Molecular descriptors
X-ray structure
Rhodopsin
Receptorome
Membrane
Antagonist
Agonist
Atypical antipsychotic drug
Typical antipsychotic drug
Side effects
Off-target
Target
Selectivity
Binding affinity
Molecular interactions
Binding site
Homology modeling
Multireceptor profile
Molecular interaction Field (MIF)
Partial Least Squares (PLS)
Principal Component Analysis (PCA)
3D Quantitave Structural-Activity-Relationship (3D
Schizophrenia
Benzolactam Derivatives
Benzofuranone Derivatives
Risperidone
Olanzapine
Clozapine
Ligand
Adrenergic receptors
Muscarinic receptors
Histamine receptors
Serotonin receptors
Dopamine receptors
beta2-Adrenergic receptor
D2 receptor
D3 receptor
5-HT2A receptor
G protein-coupled receptors (GPCR)
57
Online Access:http://hdl.handle.net/10803/7228
http://nbn-resolving.de/urn:isbn:978-84-694-2121-5

Internet

http://hdl.handle.net/10803/7228
http://nbn-resolving.de/urn:isbn:978-84-694-2121-5

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