Mechanism of regulation of the RPL30 pre-mRNA splicing in yeast

Mechanism of regulation of the RPL30 pre-mRNA splicing in yeast

The mechanisms of pre-mRNA splicing regulation are poorly understood. Here we dissect how the Saccharomyces cerevisiae ribosomal L30 protein blocks splicing of its pre-mRNA upon binding a kink-turn structure including the 5' splice site. We show that L30 binds the nascent RPL30 transcript witho...

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Bibliographic Details
Main Author: Macías Ribela, Sara
Other Authors: Vilardell, Josep
Format: Doctoral Thesis
Language:English
Published: Universitat Pompeu Fabra 2008
Subjects:
poylpyrimidine tract (Ppy tract)
branch site (BS)
' splice site (3'ss)
5' splice site (5'ss)
intron
L30
RPL30
U2 snRNP
U1 snRNP
transcription
regulation of splicing
spliceosome assembly
splicing
gene expression
57
Online Access:http://hdl.handle.net/10803/7112
http://nbn-resolving.de/urn:isbn:9788469216910

Internet

http://hdl.handle.net/10803/7112
http://nbn-resolving.de/urn:isbn:9788469216910

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